Publication details

Molekulární podstata Waldenströmovy makroglobulinemie

Title in English Molecular Basis of Waldenström Macroglobulinemia
Authors

ŠEVČÍKOVÁ Sabina NOVÁK Luboš KUBICZKOVÁ Lenka DEMENTYEVA Elena Vladimirovna ŘÍHOVÁ Lucie HÁJEK Roman

Year of publication 2012
Type Article in Periodical
Magazine / Source Klinická onkologie
MU Faculty or unit

Faculty of Medicine

Citation
Web http://www.linkos.cz/casopis-klinicka-onkologie/hledani-clanku/skupina/a/zobrazit/ids/4148/
Field Oncology and hematology
Keywords Waldenström macroglobulinemia; IL-6; SDF-1; PLyS; PI3K/Akt; NF-kappaB; JAK/STAT
Attached files
Description Waldenström macroglobulinemia is a rare lymphoproliferative disease that is currently clasified into lymphomas with incidence of 3 cases per million. This disease comprises about 1–2% of hematological malignancies and is characterized by infiltration of malignant B cells into the bone marrow and presence of monoclonal immunoglobulin IgM in serum. WM is still an incurable disease with median survival of 5 years. Molecular basis of this disease remains unclear even though deletion of 6q, trisomy of chromosomes 4 and 8, deletion of 13q and increased expression of IL-6 seem to be typical for this disease. The most important changes of microRNA are increased expression of miR-155 and decreased expression of miR-9*. This work aims to describe current knowledge about the molecular basis of this disease.
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