Publication details
Možnosti modulace průběhu kardiovaskulárních chorob
| Title in English | Possible modulation of the course of cardiovascular diseases |
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| Authors | |
| Year of publication | 2012 |
| MU Faculty or unit | |
| Citation | |
| Description | Lot of attention is paid to vitamin D in last few years due to brighter spectrum of influence in human organs. As a main mechanism of action are proved nuclear vitamin D receptors (VDR). More and more evidence of negative influence of vitamin D deficit on cardiovascular system appears together with low vitamin D serum levels in current population mostly due to life style with little exposition of unprotected skin to sun beams. The course of ischemic heart disease can be worsened by low serum level of vitamin D because of higher risk of myocardial infarction a cardiac failure with more frequent hospitalisations. Higher risk of arrythmias during vitamin D deficiency is explained by higher production of parathormone and its binding to receptors stimulating phospholipase C followed by increased activity of catecholamines, angiotensin II and endothelin in ischaemic myocardium. There is no evidence of any association of vitamin D and cholesterol levels, on the other hand normal level of vitamin D helps to keep the triglyceride serum concentration in normal range. Hypertension is influenced negatively by low level of vitamin D due to stimulation of renin-angiotensin-aldosteron system, parathormon secretion and lower antiiflammatory and vasculoprotective effect. Conclusion. The course of cardiovascular diseases can be positively modulated by keeping vitamin D level within normal range. The adequate exposition od unprotected skin to sun is to recommend for the supplementation as a nature and effective source of vitamin D. |
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