Publication details

Získaná hemofile A s těžkým průběhem – kazuistika

Title in English A severe course of acquired haemophilia A – case report


Year of publication 2012
Type Article in Periodical
Magazine / Source Anesteziologie a intenzivní medicína
MU Faculty or unit

Faculty of Medicine

Field Other specializations of internal medicine
Keywords case report; coagulation; circulating anticoagulant; factor VIII inhibitor
Description Circulating anticoagulants are endogenous substances interfering in the coagulation cascade, which may even lead to severe bleeding. In the vast majority of cases, these substances are immunoglobulins, production of which may be induced by the administration of coagulation factor concentrates, e. g. in haemophilia patients. However, they can also be associated with malignant neoplasms, drug interactions and old age. The authors present a case report of an 84-years-old female patient in whom factor VII inhibitor was detected following urological surgery. Although diagnostic tests for anticoagulants were negative prior to surgery, the patient developed coagulation inhibitors afterwards – most probably due to numerous blood transfusions. The patient died on the 5th day in spite of early detection of anticoagulant production and subsequent complex therapy.

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