Publication details

Vliv kombinace pronační polohy a vysokofrekvenční oscilační ventilace na výměnu krevních plynů u experimentálního modelu syndromu akutní respirační tísně

Title in English Effect of combination of prone position and high-fre¬quency oscillatory ventilati¬on on blood gas exchange in experimental model of acute respiratory distress syndrome


Year of publication 2013
Type Article in Periodical
Magazine / Source Anesteziologie & intenzivní medicína
MU Faculty or unit

Faculty of Medicine

Field Paediatry
Keywords acute respiratory distress syndrome; experiment; oxygenation; ventilation; prone position
Description The aim of the study was verification of the effect of combination of high-frequency oscillatory ventilation and prone position in an experimental model of acute respiratory distress syndrome. Experimental study. The study included 40 experimental piglets. Lung damage was induced by repeated bilateral lung lavage with saline to achi-eve Pa02/Fi02 < 100 mm Hg. The experimental animals were randomized into 5 groups - control group (PCV in supine position throughout the ex-periment), PP (PCV in prone position and then in supine position), HFOV (HFOV in supine position throughout the expe-riment), HFOV + PP (HFOV in supine position, after 6 hours of prone position and then supine position), PP + HFOV (PCV in prone position, after 6 hours HFOV, further rotation of supine and prone positions, as the PP group). In terms of oxyge-nation (Pa02) there was no difference between the PP and HFOV groups, higher values of Pa02 were achieved in the PP+HFOV group than in the HFOV+PP group. C0_, elimination was better in the HFOV+PP group than in the PP+HFOV group. There was no difference between the PP and HFOV groups. There was no difference in oxygenation index between the PP and HFOV groups, the PP+HFOV group had a lower oxygenation index than the HFOV + PP group. There were no differences in oxygenation and C02 elimination between the prone position and high-frequency oscillation groups. The combination of PP HFOV is more efficient in terms of oxygenation.

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