Publication details

Elimination Voltammetry as an Effective and Sensitive Electroanalytical Tool


TRNKOVÁ Libuše PILAŘOVÁ Iveta JELEN František ADAM Vojtech KIZEK René

Year of publication 2013
Type Article in Proceedings
Conference 64th Annual Meeting of the International Society of Electrochemistry, book of abstracts
MU Faculty or unit

Faculty of Science

Field Electrochemistry
Keywords biosensor;electrochemistry;elimination voltammetry with linear scan;EVLS
Description Nowadays, the electrochemical techniques are used not only for direct determination of biologically important molecules but also for suggestions of low-cost and sensitive biosensors where various modifications of working electrode surface are used enabling analyses of grave diseases. Nevertheless techniques, which are possible to use for treatment of electrochemical signals, have changed only little during past twenty years and their drawbacks persist. We propose a very interesting solution for addressing the major shortcomings of linear sweep and square vawe voltammetry (low sensitivity, high proportion of capacitive current component, and skewing of overlapping signals) in the form of elimination voltammetry (EV). Based on the different dependencies of the particular currents from which the voltammetric response is composed (i.e. difussion, charging, kinetic, etc.) on scan rate, the EV is able to eliminate or conserve the chosen current components. The contribution summarizes successful applications of this method in the electroanalysis of biomolecules, especially of nucleic acids and their components. EV is a highly sensitive method for electroactive substances which are adsorbed on the electrode surface. It has been found that EV is able to: (a) to detect the processes hidden in the predominant current, such as the discharge of the supporting electrolyte, (b) to increase the sensitivity of voltammetry at least one order of magnitude, (c) to determine the charge transfer coefficient, and (d) to detect a chemical reaction preceding the electron transfer. Thus, the EV offers a new tool contributing to better understanding of basic electrochemical processes on an electrode surface and being capable to markedly improve the sensitivity of voltammetric assays.
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