Publication details

Epigenetické účinky cigaretového kouře v procesu karcinogeneze

Title in English Epigenetic effects of cigarette smoke in carcinogenesis

HRUBÁ Drahoslava

Year of publication 2013
Type Article in Periodical
Magazine / Source Hygiena
MU Faculty or unit

Faculty of Medicine

Field Other medical specializations
Keywords corcinogenesis; epigenetics; cigarette smoke
Description Cigarette smoke contains unique amounts of human carcinogens, including tobacco-specific nitrosammes and polycychc aromatic hydrocarbons. These two families of genotoxic cliemicals and nicotine also play an important role in stages of tumorigencsis promotion and progression through epigenetic (non-genotoxic) mechanisms. Probably the most important pathways are activation of certain nicotinic acctylcholine receptors (iiAChR), p adrenoreccptors (ji AR) and aryl hydrocarbonc receptors (AhR) by these chemicals. The activation of these receptors results in the release ot growth factors and neurotransmitters which influence cell proliferation and protein synthesis, inhibition of apoptosis, mitochondria! dysfunction, angiogenesis, tumor invasion and metastasis.

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