Publication details
Epigenetické účinky cigaretového kouře v procesu karcinogeneze
| Title in English | Epigenetic effects of cigarette smoke in carcinogenesis |
|---|---|
| Authors | |
| Year of publication | 2013 |
| Type | Article in Periodical |
| Magazine / Source | Hygiena |
| MU Faculty or unit | |
| Citation | |
| Field | Other medical specializations |
| Keywords | corcinogenesis; epigenetics; cigarette smoke |
| Description | Cigarette smoke contains unique amounts of human carcinogens, including tobacco-specific nitrosammes and polycychc aromatic hydrocarbons. These two families of genotoxic cliemicals and nicotine also play an important role in stages of tumorigencsis promotion and progression through epigenetic (non-genotoxic) mechanisms. Probably the most important pathways are activation of certain nicotinic acctylcholine receptors (iiAChR), p adrenoreccptors (ji AR) and aryl hydrocarbonc receptors (AhR) by these chemicals. The activation of these receptors results in the release ot growth factors and neurotransmitters which influence cell proliferation and protein synthesis, inhibition of apoptosis, mitochondria! dysfunction, angiogenesis, tumor invasion and metastasis. |