Publication details

Transmission of t(11;14)-positive cells by allogeneic stem cell transplant: 10-year journey to mantle cell lymphoma

Authors

JANÍKOVÁ Andrea MARECKOVA Andrea BAUMEISTEROVA A. KREJČÍ Marta ŠUPÍKOVÁ Jana ŠÁLEK David HORKÝ Ondřej TICHÝ Boris HANKE Ivo POSPÍŠILOVÁ Šárka MOULIS Mojmír MAYER Jiří

Year of publication 2014
Type Article in Periodical
Magazine / Source LEUKEMIA & LYMPHOMA
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.3109/10428194.2013.858150
Field Oncology and hematology
Keywords BONE-MARROW-TRANSPLANTATION; POLYMERASE-CHAIN-REACTION; CLONAL IMMUNOGLOBULIN; RELAPSE; GENE
Attached files
Description Mantle cell lymphoma (MCL) is considered, with some exceptions, to be one of the most aggressive lymphomas, with relatively short median survival [1]. Th e biological hallmark of MCL is t(11;14)(q13;q32) resulting in cyclin D1 overexpression, which is not usually expressed in normal B cells [2]. Although the initial oncogenic translocation is acquired at the pre-B stage during the V(D)J recombination in the bone marrow [3], MCL is composed of mature B cells that grow in the mantle zone of lymphatic follicles and express the corresponding phenotype. To date, the oncogenic steps from the early event to the development of MCL have not been well documented. Rare cases of donor-derived malignancies can provide better insights into the biology and growth of different tumors under real conditions.