Publication details
Toxická epidermální nekrolýza a Stevensův Johnsonův syndrom: současné poznatky
| Title in English | Toxic epidermal necrolysis and Stevens Johnson syndrome: current knowledge |
|---|---|
| Authors | |
| Year of publication | 2014 |
| Type | Article in Periodical |
| Magazine / Source | Česká dermatovenerologie |
| MU Faculty or unit | |
| Citation | |
| Field | Dermatovenerology |
| Keywords | toxic epidermal necrolysis; Stevens-Johnson syndrome; intravenous immunoglobulin; severe adverse drug reaction |
| Description | Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are the most severe adverse cutaneous and mucosal reactions with low incidence and high morbidity and mortality, usually induced by drugs. They are characterized by massive apoptosis of keratinocytes, clinically manifesting as erythema of the skin and mucous membranes, blisters and epidermal detachment. Managing of therapy requires rapidly established diagnosis, identification and interruption of the culprit drug, supportive care and eventually immunomodulating therapy. More than 50 % of patients surviving TEN suffer from long-term sequelae of the disease (e.g. scarring and strictures). |