Publication details
SEVEN DAYS AMBULATORY BLOOD PRESSURE MONITORING: DETERMINATION OF HIGH BLOOD PRESSURE RISK FOR STROKE
| Authors | |
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| Year of publication | 2014 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Objective: The determination ot risk of mortality and morbidity based on the linear relationship between logarithm of risk and systolic i SBP) and diaslohc blood pressure (DBP) doesn't take into account the circadian variation of blood pressure (BPi followed by ambulatory BP monitoring. We suppose that determination of risk for every measured value of BP followed by calculation of mean risk value is better than calculation of daily mean BP value used later for risk calculation. The analysis of the relationship between amplitude (A) of circadian BP variation and risk was the aim ot the present paper. Design and method: Ninety-two subjects without antihypertensive therapy (age between 20 and 80 years) were recruited for 7-da> ambulatory BP monitoring (TM-2421 A and D, Japan). The obtained data uere fitted with sinusoid curve (wave length 24 hours) by the least square method and mean value, so called mesor (M) and amplitude (A) were determined for every subject. Double amplitude roughly corresponds to the night-day BP difference. Results: The data for SBP were M between 100 and ISSmmHg. We have found M of DBP to be between 60 and 98 mmlIg in our subjects The range of A was 2 to 19 mmHg. A between 2 and 23 mmllg. The mathematical analysis revealed A value to he more important in DBP than in SBP Rqual A of DBP is more important in high DBP than in low DBP. The quantitative examples ol DBP are as follows Assuming risk of stroke at M 9] mmllg and A 2 mmHg 1.0. then risk at M 60 mmllg and A 2 mmHg is 0 12, risk at M 60 mmllg and A 20 mmHg is 0.17, risk at M 100 mmHg and A 2 mmHg is 1 87 and risk at M 100 mmHg and A 20 mmHg is 2.87. Conclusions: It is concluded that the increase of amplitude of circadian variation of DBP increases the risk of stroke, especially al high DBP mean values. |