Publication details

Analyzing the defense strategies of Staphylococcus aureus strains against polyvalent bacteriophages

Authors

VARGA Marian ZOUHAROVÁ Monika PANTŮČEK Roman MOŠA Marek DOŠKAŘ Jiří

Year of publication 2014
Type Conference abstract
MU Faculty or unit

Faculty of Science

Citation
Description The emergence and alarming increase of multiresistant strains of Staphylococcus aureus emphasizes the need for new and inovative antimicrobial strategies. One of them is phage therapy that represents a promising alternative to the use of antibiotics for combating bacterial infections. Some strains, however, are resistant to therapeutic bacteriophages, which may decrease the effectivity of phage-based drugs. In our study, we analyzed causes responsible for this resistance, mainly: (i) efficacy of phage adsorption to bacterial cells; (ii) interference with the products of the prophage-borne genes in lysogenic strains; and (iii) effect of CRISPR-Cas elements.
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