Publication details

Determination of binding constant of 1st generation antidiabetic drug with human serum albumin

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Year of publication 2014
Type Article in Proceedings
Conference 11 th International Interdisciplinary Meeting on Bioanalysis CECE 2014
MU Faculty or unit

Faculty of Science

Web Oficiální stránky konference
Field Biochemistry
Keywords capillary electrophoresis - frontal analysis; 1st generation anitiabetic drugs; HSA
Description The capillary electrophoresis fontal analysis (CE-FA) was used to study the affinities between selected 1st generation antidiabetic drugs (tolbutamide, chlorpropamide) and human serum albumin (HSA). The binding constant (Kb) was measured under physiological conditions. The log Kb values obtained by means of CE-FA have a good repeatability (RSD < 3%).
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