Publication details

Exposure to secondhand tobacco smoke and lung cancer by histological type: A pooled analysis of the International Lung Cancer Consortium (ILCCO)

Authors	KIM Claire H. LEE Yuan-Chin Amy HUNG Rayjean J. MCNALLAN Sheila R. COTE Michele L. LIM Wei-Yen CHANG Shen-Chih KIM Jin Hee UGOLINI Donatella CHEN Ying LILOGLOU Triantafillos ANDREW Angeline S. ONEGA Tracy DUELL Eric J. FIELD John K. LAZARUS Philip MARCHAND Loic Le NERI Monica VINEIS Paolo KIYOHARA Chikako HONG Yun-Chul MORGENSTERN Hal MATSUO Keitaro TAJIMA Kazuo CHRISTIANI David C. MCLAUGHLIN John R. BENCKO Vladimir HOLCATOVA Ivana BOFFETTA Paolo BRENNAN Paul FABIANOVA Eleonora FORETOVÁ Lenka JANOUT Vladimir LISSOWSKA Jolanta MATES Dana RUDNAI Peter SZESZENIA-DABROWSKA Neonila MUKERIA Anush ZARIDZE David SEOW Adeline SCHWARTZ Ann G. YANG Ping ZHANG Zuo-Feng
Year of publication	2014
Type	Article in Periodical
Magazine / Source	International Journal of Cancer
MU Faculty or unit	Faculty of Medicine
Citation
Doi	http://dx.doi.org/10.1002/ijc.28835
Field	Oncology and hematology
Keywords	lung cancer; secondhand smoke; environmental tobacco smoke; involuntary smoking; International Lung Cancer Consortium
Description	While the association between exposure to secondhand smoke and lung cancer risk is well established, few studies with sufficient power have examined the association by histological type. In this study, we evaluated the secondhand smoke-lung cancer relationship by histological type based on pooled data from 18 case-control studies in the International Lung Cancer Consortium (ILCCO), including 2,504 cases and 7,276 control who were never smokers and 10,184 cases and 7,176 controls who were ever smokers. We used multivariable logistic regression, adjusting for age, sex, race/ethnicity, smoking status, pack-years of smoking, and study. Among never smokers, the odds ratios (OR) comparing those ever exposed to secondhand smoke with those never exposed were 1.31 (95% Cl: 1.17-1.45) for all histological types combined, 1.26 (95% Cl: 1.10-1.44) for adenocarcinoma, 1.41 (95% Cl: 0.99-1.99) for squamous cell carcinoma, 1.48 (95% Cl: 0.89-2.45) for large cell lung cancer, and 3.09 (95% Cl: 1.62-5.89) for small cell lung cancer. The estimated association with secondhand smoke exposure was greater for small cell lung cancer than for nonsmall cell lung cancers (OR= 2.11, 95% Cl: 1.11-4.04). This analysis is the largest to date investigating the relation between exposure to secondhand smoke and lung cancer. Our study provides more precise estimates of the impact of secondhand smoke on the major histological types of lung cancer, indicates the association with secondhand smoke is stronger for small cell lung cancer than for the other histological types, and suggests the importance of intervention against exposure to secondhand smoke in lung cancer prevention.