Publication details

Neuropsychologický výkon u pacientů s první epizodou schizofrenie

Title in English Neuropsychological Performance with First- episode of Schizophrenia


Year of publication 2015
Type Article in Periodical
Magazine / Source Česká a Slovenská neurologie a neurochirurgie
MU Faculty or unit

Faculty of Medicine

Field Psychiatry, sexuology
Keywords cognitive functioning dynamics; cognitive performance; neuropsychology; schizophrenia
Description Neuropsychological examination is becoming an integral part of the diagnostic process in many neurological and psychiatric disorders. neuropsychological profile has now been successfully defined for a number of diagnoses that enable estimation of future cognitive functioning. In psychiatry, neuropsychology is most frequently used to assess cognitive functioning in patients with schizophrenia the objective of this study. The study aims to determine the progress of cognitive functioning in patients with schizophrenia, specifically to assess cognitive performance during the first episode of schizophrenia and one year later. 82 hospitalized patients with paranoid schizophrenia have completed a comprehensive examination by internationally used neuropsychological methods. One year later, 39 patients completed a follow up examination. Results of the examination showed deterioration of cognitive functioning on the majority of cognitive domains during the first episode, expressed as the mean score lower than 1 of z-score. Cognitive weakening was significant in verbal and visual memory, psychomotor speed, distribution of attention and verbal fluency. Comparing the results of neuropsychological tests during the first episode of schizophrenia and a year after, we found out that cognitive performance improved in all observed domains. We found a statistically significant change (p < 0.05) in delayed verbal memory (AVLT 30: t = -3.19; p = 0.003), immediate visual memory (ROCF RE: t = -4.52; p = 0.001) and psychomotor speed (TMT A: t = -2.72; p = 0.01). Despite statistically significant change in AVLT 30, performance in auditory memory remained on the level of cognitive weakening in the majority of assessed criteria.

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