Publication details

Nové trendy ve studiu glykosylace proteinů u onkologických onemocnění

Title in English New Trends in the Study of Protein Glycosylation in Oncological Diseases


Year of publication 2014
Type Article in Periodical
Magazine / Source Klinická onkologie
Keywords glycomics, glycopeptides, cancer, liquid chromatography, mass spectrometry, capillary electrophoresis, glycan profiling, array analysis
Description Glycomics and glycoproteomics represent relatively new directions in detail analyses of complex bio logical media. These areas of increasing importance to cancer research complement the more established genomic profiling and proteomics. Glycoproteins are being increasingly recognized as important in cellular interactions and adhesion. Structural alterations of their glycan moieties seem to occur in different cancer conditions.We review current directions in glycomic profiling and glycoproteomic investigations of bio logical fluids and tissues pertaining to cancer. The used methods rely on capillary separation techniques, mass spectrometry, and the glycan and lectin arrays. They all show considerable promise for new dia gnostic and prognostic measurements.

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