Publication details

Incorporation of humanized niche as a strategy for improving leukemic engraftment in immunodeficient mice

Authors

ČULEN Martin DVOŘÁKOVÁ D. SEMERÁD Lukáš ŠUSTKOVÁ Zuzana BOUCHNEROVÁ Jana PALACKOVÁ Martina MAYER Jiří RÁČIL Zdeněk

Type Article in Periodical
Magazine / Source Transfuze a hematologie dnes
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords bone marrow; microenvironment; scaffold; biomaterial; leukemia; mesenchymal stromal cell
Description In vivo models of patient derived leukemias are utilized using immunodeficient mice that provide engraftment of xeno--transplanted leukemic cells without their rejection. Despite the achievement of considerable immunosuppression in the latest immunecompromised mouse, engraftment of patient samples is still not always possible or does not fully reflect the original disease characteristics. This points to the presence of inter-species differences in the hematopoietic niche. In order to improve engraftment options, a valid proposition is to model the human niche in mice. In recent years, this has been performed by adopting an osteogenic approach already used in bone-regenerative medicine and based on using a suitable biomaterial along with mesenchymal stromal cells capable of bone-formation. The review aims to present and discuss works describing leukemic engraftment in a hybrid-mouse model containing a humanized microenvironment and to point out important details and possible future directions of this research.
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