Publication details

Endoluminal radiofrequency ablation of malignant biliary stenoses

Authors

ANDRAŠINA Tomáš PÁNEK Jiří HLAVSA Jan BERNARD Vladan VÁLEK Vlastimil

Year of publication 2015
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Purpose: To prove efficacy of endoluminal radiofrequency ablation before stenting of malignant biliary stenoses. Methods and Materials: 54 patients with histologically proven malignant biliary stenoses have been enrolled in a prospective randomised study from 2010. 73 non-covered self-expandable metal stents were inserted. In group A (n=22) the endoluminal ablation with a bipolar radiofrequency catheter (EndoHPB;EMcision Ltd.,London,UK) was performed 0-48hours prior to the stent insertion, in group B (n=32) the stent was implanted without a prior ablation. The primary endpoints of the study were to determine the rate of complications, duration of stent patency and survival of patients (Kaplan-Meyer analysis). Results: No major complications related to the stent insertion and endoluminal ablation were recorded. 30 day mortality was 3.7%. The average primary stent patency was 5.6 and 5.2 months in group A and B, respectively, 3-months and 6-months stent failure was 9.1% and 13.6% in group A and 15% and 25% in group B. The median survival from the insertion of the stent was 5.9 (2.9-6.7) and 5.4 (3.7-8.6) months, the median survival from the initial drainage was 9.6 (5.6-12.2) and 8.5 (5.8-12.7) months in group A and B, respectively. The difference was not statistically significant. Conclusion: In the prospective randomised clinical study the effect of an endoluminal ablation on patients survival was not proven. However, in the group of patients undergoing ablation there is a tendency of a lower rate of early stent failure. In addition, the intervention was not associated with higher rates of complications.
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