Publication details

Pentelková grafitová elektroda jako vhodný nástroj pro analýzu methyladeninů

Title in English Pencil Graphite Electrode as a Suitable Sensor for Methyladenines Analysis


Year of publication 2016
Type Article in Proceedings
Conference XXXVI. Moderní Elektrochemické Metody
MU Faculty or unit

Faculty of Science

Field Physical chemistry and theoretical chemistry
Keywords adenine; 3N-methyladenine; square-wave voltammetry; pencil graphite electrode; glassy carbon electrode
Description Purine derivatives play key role in human metabolism. Adenine, as a part of DNA, is constantly being attacked by many species which can form many different products, such as oxidized forms. Metyl group have been commonly observed in the case of DNA damage. Adenine can be methylated at different purine ring positions. There are so far few electrochemical studies describing oxidation processes in N-methylated adenines. We found out the possibility of measuring 3N-methyladenine (3N-mAde) on PeGE using electrode surface prereatment, due to unique surface morphology, followed by adsorption. we did not obtain signals at glassy acrbon electrode at same experimental conditions.
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