Publication details

Paraneoplastické neurologické syndromy u gynekologických malignit

Title in English Paraneoplastic neurological syndromes in gynecological malignancies


Year of publication 2016
Type Article in Periodical
Magazine / Source Česká gynekologie
MU Faculty or unit

Faculty of Medicine

Field Gynaecology and obstetrics
Keywords paraneoplastic neurological syndrome; malignant germinal ovarian tumor; anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDAR encephalitis)
Description Objective: The demonstration of life-threatening paraneoplastic syndrome with dominant neurological symptomatology in germinal ovarian malignancy. Design: Literature review with case report. Setting: Department of Gynecology and Obstetrics, Faculty of Medicine Masaryk University and UniversityHospital Brno. Methods: The review outlines the issue of paraneoplastic syndromes. It describes the etiopathogenesis, the range of clinical symptoms, the diagnostic and therapeutic possibilities, along with a relevant case study which focuses on the paraneoplastic neurological symptoms in malignant germinal ovarian tumor. Conclusion: Although paraneoplastic symptomatology is rather rare, it constitutes an important part of the clinical picture of malignant tumors. In a number of cases, the paraneoplastic neurological syndrome (PNNS) symptoms precede the actual tumor diagnosis. The awareness of this connection can thus be important in early diagnostics, which in turn can significantly affect a patient‘s prognosis. Another important benefit of familiarity with the symptoms of neurological paraneoplasia is the factthat some PNNS are associated with specific tumors. Interdisciplinary cooperation is necessary in the case of PNNS for early tumor diagnostics. Treatment of the primary tumor is the key in diagnosed malignancies. With effective oncological treatment, adequate regression of paraneoplastic symptoms can be observed.

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