Publication details

Vitamin D receptor TaqI gene polymorphism and dental caries in Czech children

Authors

IZAKOVIČOVÁ HOLLÁ Lydie BOŘILOVÁ LINHARTOVÁ Petra KAŠTOVSKÝ Jakub BARTOŠOVÁ Michaela MUSILOVÁ Kristína KUKLA Lubomír KUKLETOVÁ Martina

Year of publication 2017
Type Article in Periodical
Magazine / Source Caries Research
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1159/000452635
Field ORL, ophthalmology, stomatology
Keywords case-control study; dental caries; gene polymorphism; Gingivitis; Vitamin D receptor
Description Aim: We analyzed the VDR TaqI (rs731236) gene polymorphism in children with and those without dental caries. Methods: A total of 388 subjects, 153 caries-free (with decayed/missing/filled teeth [DMFT] = 0) and 235 children with dental caries (DMFT >=1), were genotyped by the TaqMan method. Results: Although no significant differences in VDR TaqI allele and genotype frequencies between caries-free and caries-affected children were detected, a significant association between this polymorphism and gingivitis was found (p < 0.05). Conclusions: In contrast to previous studies from China and Turkey, the VDR TaqI gene variant cannot be used as a marker for identification of Czech children with increased dental caries risk.
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