Publication details

Léčba refrakterních a relabovaných sarkomů měkkých tkání

Title in English Current treatment strategies for refractory or relapsed soft tissue sarcomas
Authors

MÚDRY Peter MAZÁNEK Pavel ROHLEDER Ondřej MELICHÁRKOVÁ Kristýna BAJČIOVÁ Viera

Year of publication 2016
Type Article in Periodical
Magazine / Source Ortopedie
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords soft tissue sarcoma; doxorubicin; tyrosine kinase inhibitors; angiogenesis; immunotherapy; metronomic therapy
Description The soft tissue sarcomas are heterogeneous group of malignancies. Mainstay of first line treatment is radical surgery, while chemotherapy has doubtful results across published studies and is effective for only some types of sarcomas. Refractory and relapsed soft tissue sarcomas are difficult to treat, with some exceptions. Some of the possible methods are limited by their toxicity. New therapeutic procedures include metronomic antiangiogenic therapy and immunotherapies, and they are under evaluations in ongoing clinical trials.
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