Publication details

Teratogenic effects of five anticancer drugs on Xenopus laevis embryo

Authors

ISIDORI Marina PISCITELLI Concetta RUSSO Chiara SMUTNÁ Marie BLÁHA Luděk

Year of publication 2016
Type Article in Periodical
Magazine / Source Ecotoxicology and Environmental Safety
MU Faculty or unit

Faculty of Science

Citation
Web http://www.sciencedirect.com/science/article/pii/S0147651316302500
Doi http://dx.doi.org/10.1016/j.ecoenv.2016.06.044
Field Environment influence on health
Keywords Anticancer drugs; FETAX; Teratogenicity; Xenopus laevis
Description In recent years, the environmental presence of pharmaceuticals - including anticancer drugs - is an emerging issue. Because of the lack of appropriate critical studies about anticancer drug effects in frogs, the aim of the present study was to investigate lethal and teratogenic effects of five anticancer drugs widely used in large quantities, i.e. 5-flourouracil, capecitabine, cisplatin, etoposide, and imatinib, in the embryos of the South African clawed frog, Xenopus laevis, using FETAX - Frog Embryo Teratogenesis Assay in Xenopus. None of the studied anticancer drugs induced statistically significant mortality within the concentrations tested (0.01-50mg/L, depending on the studied compound), and no growth inhibition of embryos after a 96-h exposure was observed. Except for cisplatin, the other pharmaceuticals induced an increase of developmental malformations such as abdominal edema, axial flexure, head, eyes, gut and heart malformations with statistically significant effects observed at the highest concentrations tested (50 mg/L for 5-flourouracil; 30 mg/L for etoposide and 20 mg/L for capecitabine and imatinib). The results indicate that anticancer drugs can affect embryogenesis mechanisms.
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