Publication details

Menstrual and Reproductive Factors, Hormone Use, and Risk of Pancreatic Cancer: Analysis From the International Pancreatic Cancer Case-Control Consortium (PanC4)

Authors	LUJAN-BARROSO Leila ZHANG Wei OLSON Sara H. GAO Yu-Tang YU Herbert BAGHURST Peter A. BRACCI Paige M. BUENO-DE-MESQUITA Bas H. FORETOVÁ Lenka GALLINGER Steven HOLCATOVA Ivana JANOUT Vladimir JI Bu-Tian KURTZ Robert C. LA VECCHIA Carlo LAGIOU Pagona LI Donghui MILLER Anthony B. SERRAINO Diego ZATONSKI Witold RISCH Harvey A. DUELL Eric J.
Year of publication	2016
Type	Article in Periodical
Magazine / Source	Pancreas
MU Faculty or unit	Faculty of Medicine
Citation
Doi	http://dx.doi.org/10.1097/MPA.0000000000000635
Field	Oncology and hematology
Keywords	pancreatic cancer; menstrual and reproductive factors; exogenous hormones; hysterectomy; consortium
Description	Objectives We aimed to evaluate the relation between menstrual and reproductive factors, exogenous hormones, and risk of pancreatic cancer (PC). Methods Eleven case-control studies within the International Pancreatic Cancer Case-control Consortium took part in the present study, including in total 2838 case and 4748 control women. Pooled estimates of odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated using a 2-step logistic regression model and adjusting for relevant covariates. Results An inverse OR was observed in women who reported having had hysterectomy (ORyesvs.no, 0.78; 95% CI, 0.67-0.91), remaining significant in postmenopausal women and never-smoking women, adjusted for potential PC confounders. A mutually adjusted model with the joint effect for hormone replacement therapy (HRT) and hysterectomy showed significant inverse associations with PC in women who reported having had hysterectomy with HRT use (OR, 0.64; 95% CI, 0.48-0.84). Conclusions Our large pooled analysis suggests that women who have had a hysterectomy may have reduced risk of PC. However, we cannot rule out that the reduced risk could be due to factors or indications for having had a hysterectomy. Further investigation of risk according to HRT use and reason for hysterectomy may be necessary.