Publication details

Reprint of "DNA, the central molecule of aging"

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Year of publication 2016
Type Article in Periodical
Magazine / Source Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis
MU Faculty or unit

Faculty of Science

Field Genetics and molecular biology
Keywords DNA; Aging; Chromatin structure; Telomeres; DNA damage; DNA repair; Mutagenesis
Description Understanding the molecular mechanism of aging could have enormous medical implications. Despite a century of research, however, there is no universally accepted theory regarding the molecular basis of aging. On the other hand, there is plentiful evidence suggesting that DNA constitutes the central molecule in this process. Here, we review the roles of chromatin structure, DNA damage, and shortening of telomeres in aging and propose a hypothesis for how their interplay leads to aging phenotypes. (C) 2016 Published by Elsevier B.V.
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