Publication details

Flow cytometry in immunoglobulin light chain amyloidosis: Short review


JANA Filipová ŘÍHOVÁ Lucie VŠIANSKÁ Pavla KUFOVÁ Zuzana KRYUKOVA Elena Vladimirovna KRYUKOV Fedor HÁJEK Roman

Year of publication 2015
Type Article in Periodical
Magazine / Source Leukemia Research
MU Faculty or unit

Faculty of Medicine

Field Genetics and molecular biology
Keywords Flow cytometry; AL amyloidosis; Monoclonal gammopathy; Plasma cell
Description Flow cytometry (FCM) has found its application in clinical diagnosis and evaluation of monoclonal gammopathies (MG). Although, research has been mainly focused on multiple myeloma (MM), nowadays FCM becomes to be potential tool in the field of AL amyloidosis. Clonal plasma cells identification and specific phenotype profile detection is important for diagnosis, monitoring and prognosis of AL amyloidosis. Therefore, FCM could be a perspective method for study not only MM but also AL amyloidosis. This review provides an overview and possibilities of FCM application in AL amyloidosis.

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