Publication details

COBLL1, LPL and ZAP70 expression defines prognostic subgroups of chronic lymphocytic leukemia patients with high accuracy and correlates with IGHV mutational status

Authors

PLEŠINGEROVÁ Hana LIBROVA Zuzana PLEVOVÁ Karla LIBRA Antonín TICHÝ Boris SKUHROVÁ FRANCOVÁ Hana VRBACKY Filip SMOLEJ Lukáš MAYER Jiří BRYJA Vítězslav DOUBEK Michael POSPÍŠILOVÁ Šárka

Year of publication 2017
Type Article in Periodical
Magazine / Source LEUKEMIA & LYMPHOMA
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://www.tandfonline.com/doi/full/10.1080/10428194.2016.1180690
Doi http://dx.doi.org/10.1080/10428194.2016.1180690
Field Oncology and hematology
Keywords Chronic lymphocytic leukemia; COBLL1; IGHV mutational status; LPL; prognosis; ZAP70
Description The clinical course of chronic lymphocytic leukemia (CLL) is highly variable. Patients with unmutated IGHV (U-CLL) usually progress rapidly, whereas patients with mutated IGHV (M-CLL) have a more indolent disease. The expression of several genes correlates closely with the IGHV mutational status and could be used to assess prognosis in CLL. We analyzed the prognostic relevance of COBLL1, LPL, and ZAP70 gene expression, which correlated with IGHV mutational status (p< 0.0001), in 117 CLL patients and established a prognostic parameter dividing the tested cohort according to the disease aggressiveness. Our prognostic parameter was validated on an independent cohort of 161 CLL patients and achieved a high accuracy (94%). Patients divided according to the prognostic parameter differ in overall survival and time to first treatment (p< 0.0001, HR = 2.300/5.970, 95% CI: 1.587-3.450/4.621-15.86). Our approach provides a reliable alternative method to prognosis assessment via IGHV mutational status analysis.
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