Publication details
Label-free detection of canonical DNA bases, uracil and 5-methylcytosine in DNA oligonucleotides using linear sweep voltammetry at a pyrolytic graphite electrode
| Authors | |
|---|---|
| Year of publication | 2017 |
| Type | Article in Periodical |
| Magazine / Source | ELECTROCHEMISTRY COMMUNICATIONS |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.sciencedirect.com/science/article/pii/S1388248117301960 |
| Doi | http://dx.doi.org/10.1016/j.elecom.2017.07.013 |
| Field | Biophysics |
| Keywords | 5-Methylcytosine; DNA; Electrochemistry; Electrochemical reduction; Electrochemical oxidation; Pyrolytic graphite |
| Description | First use of a pyrolytic graphite electrode (PGE) for electroreduction of DNA bases PGE offers DNA redox signals analogous to those of mercury-based electrodes. Novel analytically applicable redox signals of DNA bases were found. Distinct cathodic signals of A, C, G, T, mC or U can be measured at the PGE. Cathodic polarization can selectively switch off DNA anodic signals and vice versa. |