Publication details

Cellular structural biology of nucleic acids

Authors

DŽATKO Šimon KRAFČÍKOVÁ Michaela FIALA Radovan FESSL Tomáš LOJA Tomáš CARON C. GRANZHAN A. TEULADE FICHOU M.P. MERGNY J.L. TRANTÍRKOVÁ Silvie TRANTÍREK Lukáš

Type Conference abstract
MU Faculty or unit

Central European Institute of Technology

Citation
Description The nucleic acid structure, particularly that of DNA, is sensitively modulated by non-specific physical and chemical environmental factors such as nucleic acids concentration, water activity, molecular crowding, viscosity, temperature, pH and/or concentration and nature of counter ions. Existence of environmentally promoted conformational polymorphism thus indicates that characterization of DNA structure, dynamics, and DNA-ligand/protein interactions should be ideally performed under native conditions in complex environment of living cells.
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