Publication details

Both ketamine and NBQX attenuate alcohol drinking in male Wistar rats

Authors

RUDÁ Jana BABINSKÁ Zuzana ĽUPTÁK Matej GETACHEW Bruk TIZABI Yousef

Year of publication 2018
Type Article in Periodical
Magazine / Source Neuroscience Letters
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.sciencedirect.com/science/article/pii/S030439401731025X
Doi http://dx.doi.org/10.1016/j.neulet.2017.12.055
Field Pharmacology and pharmaceutical chemistry
Keywords Alcoholism; Alcohol use disorder; Glutamatergic receptors; NMDA receptor; AMPA receptor; Kainate receptor
Description Highlights: Acute low dose ketamine reduced alcohol intake but not alcohol-related behavioural effects. Acute low dose NBQX reduced alcohol intake but not alcohol-related behavioural effects. NMDA or AMPA/kainate receptor antagonists may have treatment potential in alcohol use disorder. These results suggest that selective antagonism of the NMDA or AMPA/kainate receptors may be of therapeutic potential in AUD.
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