Publication details

Cold plasma: The way to improve the SALD ICP MS analysis repeatibility

Authors

STIBOREK Marek PREISLER Jan SHEKARGOFTAR Masoud KANICKÝ Viktor KELAR Jakub

Year of publication 2017
Type Article in Proceedings
Conference CECE 2017 14th International Interdisciplinary Meeting on Bioanalysis
MU Faculty or unit

Faculty of Science

Citation
Web https://cece.mik.uni-pannon.hu
Field Analytic chemistry
Keywords SALD ICP MS; ošetření plazmatem; DCSBD; mikrovzorek; interní standard
Description This work deals with the preparation of model biological microsamples for Substrate Assisted Laser Desorption Inductively Coupled Plasma Mass Spectrometry (SALD ICP MS). This technique provides direct and fast analysis of liquid samples deposited onto polyethylene terephthalate (PET) plate (substrate) in the form of dried droplets with minimal sample preparation and submicrolitre sample volume requirements. Furthermore, SALD allows direct analysis of samples in organic solvents, which cannot be directly nebulised to ICP MS. These benefits are, however, balanced out by low repeatability of the assay, typically about 30 %. One of the approaches to increasing the repeatability is a modification of the substrate surface by Diffuse Coplanar Surface Barrier Discharge (DCSBD) with an addition of an internal standard to the sample. Using this approach, a relative standard deviation under 10 % for model biological samples can be achieved. The only limitation of this technique is the occurrence of the so-called “aging effect”, i.e., the gradual return of the modified physicochemical surface properties to the original state.
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