Publication details

Reanalysis of Chinese Treponema pallidum samples: all Chinese samples cluster with SS14-like group of syphilis-causing treponemes

Authors

STROUHAL Michal OPPELT Jan MIKALOVÁ Lenka ARORA Natasha NIESELT Kay GONZÁLEZ-CANDELAS Fernando ŠMAJS David

Type Article in Periodical
Magazine / Source BMC Research Notes
MU Faculty or unit

Faculty of Medicine

Citation
WWW https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-017-3106-7
Doi http://dx.doi.org/10.1186/s13104-017-3106-7
Keywords Genome sequencing; Phylogenetic analysis; Single nucleotide variant; SyphilisTreponema pallidum
Description Treponema pallidum subsp. pallidum (TPA) is the causative agent of syphilis. Genetic analyses of TPA reference strains and human clinical isolates have revealed two genetically distinct groups of syphilis-causing treponemes, called Nichols-like and SS14-like groups. So far, no genetic intermediates, i.e. strains containing a mixed pattern of Nichols-like and SS14-like genomic sequences, have been identified. Recently, Sun et al. (Oncotarget 2016. https://doi.org/10.18632/oncotarget.10154) described a new “phylogenetic group” (called Lineage 2) among Chinese TPA strains. This lineage exhibited a “mosaic genomic structure” of Nichols-like and SS14-like lineages.
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