Publication details

Reanalysis of Chinese Treponema pallidum samples: all Chinese samples cluster with SS14-like group of syphilis-causing treponemes

Authors

STROUHAL Michal OPPELT Jan MIKALOVÁ Lenka ARORA Natasha NIESELT Kay GONZÁLEZ-CANDELAS Fernando ŠMAJS David

Type Article in Periodical
Magazine / Source BMC Research Notes
MU Faculty or unit

Faculty of Medicine Faculty of Science Central European Institute of Technology

Citation
WWW https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-017-3106-7
Doi http://dx.doi.org/10.1186/s13104-017-3106-7
Description Treponema pallidum subsp. pallidum (TPA) is the causative agent of syphilis. Genetic analyses of TPA reference strains and human clinical isolates have revealed two genetically distinct groups of syphilis-causing treponemes, called Nichols-like and SS14-like groups. So far, no genetic intermediates, i.e. strains containing a mixed pattern of Nichols-like and SS14-like genomic sequences, have been identified. Recently, Sun et al. (Oncotarget 2016. https://doi.org/10.18632/oncotarget.10154) described a new “phylogenetic group” (called Lineage 2) among Chinese TPA strains. This lineage exhibited a “mosaic genomic structure” of Nichols-like and SS14-like lineages.

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