Publication details

CD36 gene polymorphism is associated with Alzheimer's disease

Authors

ŠERÝ Omar JANOUTOVA J. EWERLINGOVÁ Laura HÁLOVÁ Alice LOCHMAN Jan JANOUT Vladimír KHAN Naim Akhtar BALCAR VJ

Year of publication 2017
Type Article in Periodical
Magazine / Source Biochimie
MU Faculty or unit

Faculty of Science

Citation
Doi http://dx.doi.org/10.1016/j.biochi.2017.01.009
Field Biochemistry
Keywords Polymorphism; Association; CD36; Gene; ApoE; MMSE
Description CD36 gene encodes a membrane glycoprotein (type B scavenger receptor) present on the surface of many types of cells and having multiple cellular functions ranging from angiogenesis to gustatory perception of fatty acids. Using a case control genetic association approach we have analyzed selected single nucleotide polymorphisms (SNP's) in a total of 859 patients with Alzheimer's disease (AD) and controls and have identified the allele A in rs3211892 polymorphism of CD36 gene as significantly increasing the risk of AD. Additionally we have investigated, in the same sample of control subjects and patients, SNP's in ApoE gene and confirmed that the previously identified AD-associated SNP's indeed increased the risk and decreased the age of onset of AD as reported by others earlier. Based on the current knowledge of CD36 biochemistry we propose that the AD risk-imparting variants of CD36 alter cholesterol homeostasis, oxidation stress or induce pathological inflammatory cascades. The SNP rs3211892 has previously been associated with heart disease and other conditions but the present study is the first to identify a significant association between variations in CD36 gene and the risk of Alzheimer's disease.
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