Publication details

Transgenerational phenotype aggravation in CAF-1 mutants reveals parent-of-origin specific epigenetic inheritance

Authors

MOZGOVÁ Iva FAJKUS Jiří WILDHABER Thomas ROSZAK Pavel TREJO-ARELLANO Minerva S. FAJKUS Jiří ROSZAK Pawel KOEHLER Claudia HENNIG Lars

Year of publication 2018
Type Article in Periodical
Magazine / Source New Phytologist
MU Faculty or unit

Faculty of Science

Citation
Web http://www.newphytologist.com
Doi http://dx.doi.org/10.1111/nph.15082
Keywords Arabidopsis thaliana; CAF-1; Chromatin; Development; DNA methylation; epigenetics; histone
Description Shoot- and root-related growth phenotypes were progressively more affected in successive generations of CAF-1 mutants. Early and late generations of the fasciata (fas)2-4 CAF-1 mutant displayed only limited changes in gene expression, of which increasing upregulation of plant defense-related genes reflects the transgenerational phenotype aggravation. Likewise, global DNA methylation in the sequence context CHG but not CG or CHH (where H = A, T or C) changed over generations in fas2-4. Crossing early and late generation fas2-4 plants established that the maternal contribution to the phenotype severity exceeds the paternal contribution.
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