Publication details

Preparation of potential platinum-based metallodrugs

Authors

JEREMIAS Lukáš MAREK Radek

Year of publication 2018
Type Appeared in Conference without Proceedings
MU Faculty or unit

Central European Institute of Technology

Citation
Description Platinum anticancer agents represent one of the great success stories in the field of medicinal inorganic chemistry. However, current chemotherapeutics are rather non-selective and their undesired reactivity during the delivery to cancer tissue is responsible for severe side effects [1]. These anticancer agents would greatly benefit from protection during the transport in blood stream, and targeted delivery towards specific cancer tissues [2]. Therefore, preparation of Pt compounds decorated with anchor-type ligands suitable for encapsulation in macrocyclic cavitands was our goal in this study. Synthesis of novel platinum coordination compounds containing bulky adamantane ligands, their characterization by heteronuclear NMR spectroscopy and binding of these complexes into macrocyclic carriers were discussed. [1] Dilruba, S., Kalayda, G. V., Platinum-based drugs: past, present and future. In Cancer Chemother. Pharmacol., 2016, vol. 77, p. 1103-1124. [2] Wang, X., Guo, Z., Targeting and delivery of platinum-based anticancer drugs. In Chem. Soc. Rev., 2013, vol. 42, p. 202-224.
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