Publication details

Comparison of Active Substance Losses and Total Weight Losses of Tablets Administered Via Feeding Tube

Authors

PAPIEŽ Adriána ODEHNALOVA Klara ŠRÁMEK Vladimír SUK Pavel

Year of publication 2019
Type Article in Periodical
Magazine / Source PHARMACOLOGY
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.karger.com/Article/FullText/496423
Doi http://dx.doi.org/10.1159/000496423
Keywords Dosage forms; Drug administration routes; Nasogastric tube; Intensive care; High-pressure liquid chromatography
Description Background/Aims: Administration of tablets via feeding tube (FT) is often associated with significant drug losses, as was confirmed by weighing. The aim of this study was to measure the proportion of active substance losses (ASLs) in an in vitro model. Methods: A film-coated tablet (FilmCT) containing clopidogrel (Trombex (R)) and a tablet with enteric coating (EntericCT) containing pantoprazole (Controloc (R)) were crushed in a mortar and transferred by method A (tablet powder was transferred into the beaker, poured into the syringe and water added) and method B (water was added into the mortar, suspension drawn into the syringe) and administered via FT in an in vitro model. Total losses were measured with analytical balance and, simultaneously, ASL were analyzed with high-performance liquid chromatography UV-detection (HPLC-UV). Results: ASL was different to weighing only in the case of EntericCT prepared by method B (2.0 +/- 4.2 and 10.7 +/- 0.8% for HPLC-UV and weighing, respectively; p = 0.004). HPLC-UV confirmed significantly lower ASL when method B was used for either EntericCT (34.3 +/- 7.2 vs. 2.0 +/- 4.2%; p < 0.001) or FilmCT (14.1 +/- 2.2 vs. 7.7 +/- 4.1%; p < 0.01). Conclusion: Drug loss analysis with analytical balance may overestimate ASL, as was proved for EntericCT in this study. ASL were significantly lower when method B was used.