Publication details
Method for identification of condition associated public antigen receptor sequences
| Authors | |
|---|---|
| Year of publication | 2018 |
| Type | Article in Periodical |
| Magazine / Source | elife |
| MU Faculty or unit | |
| Citation | |
| Web | http://dx.doi.org/10.7554/elife.33050 |
| Doi | http://dx.doi.org/10.7554/elife.33050 |
| Keywords | T-CELL REPERTOIRE; SPECIFICITY; IMMUNITY; DEEP; AGE |
| Description | Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences. We developed a statistical framework for associating receptors to disease from only a small cohort of patients, with no need for a control cohort. Our method successfully identifies previously validated Cytomegalovirus and type one diabetes responsive TCR beta sequences |