Publication details

Genetické a neurobiologické aspekty komorbidního výskytu poruch autistického spektra a epilepsie

Title in English Genetic and neurobio logical aspects of comorbid occurence of autism spectrum disorder and epilepsy
Authors

DANHOFER Pavlína HORÁK Ondřej AULICKÁ Štefánia ČESKÁ Katarína PEJČOCHOVÁ Jana FAJKUSOVÁ Lenka OŠLEJŠKOVÁ Hana

Year of publication 2019
Type Article in Periodical
Magazine / Source Ceska a slovenska neurologie a neurochirurgie
MU Faculty or unit

Faculty of Medicine

Citation
Web http://dx.doi.org/10.14735/amcsnn2019148
Doi http://dx.doi.org/10.14735/amcsnn2019148
Keywords autism; epilepsy; autism spectrum disorder; genetics; ASD
Description Autism spectrum disorder (ASD) is ranked among neurodevelopmental and neuropsychiatric disorders with clinical onset in childhood. In recent years, this disorder has come to the forefront of scientific interest, mainly due to increasing prevalence of up to 1/68 in 2014. The genetic causes of the disorder and the pathophysiological mechanisms that might be involved in the development of ASD are revealed. Comorbid occurrence with epilepsy is quite common, in up to 46% of cases. This article summarizes the cur rent knowledge in this field with a focus on the hypothesis of excitatory-inhibitory imbalance. Some genetic causes of ASD and cur rent diagnostic options are also discus sed. The pathophysiology of the co-morbidity of ASD and epilepsy is discus sed in terms of possible therapeutic interventions.
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