Publication details
Hyperglycemia potentiates the effect of ionic calcium in photoreceptor ellipsoid zone disruption in diabetic retinopathy
| Authors | |
|---|---|
| Year of publication | 2019 |
| Type | Article in Periodical |
| Magazine / Source | INTERNATIONAL OPHTHALMOLOGY |
| MU Faculty or unit | |
| Citation | |
| Web | http://dx.doi.org/10.1007/s10792-018-01063-8 |
| Doi | http://dx.doi.org/10.1007/s10792-018-01063-8 |
| Keywords | Diabetic retinopathy; Glycated hemoglobin; Serum calcium; Spectral-domain optical coherence tomography; Ellipsoid zone |
| Description | PurposeTo study the association of serum ionic calcium and glycated hemoglobin (HbA1c) with retinal photoreceptor ellipsoid zone (EZ) disruption in diabetic retinopathy (DR). MethodsThis is a tertiary care center-based observational cross-sectional study. Sixty-three consecutive cases, divided into 21 cases each with no diabetic retinopathy, non-proliferative diabetic retinopathy and proliferative diabetic retinopathy were included. Twenty-one healthy controls were also included. Ellipsoid zone disruption was assessed using spectral-domain optical coherence tomography. Serum ionic calcium and HbA1c were measured using standard protocol. Patient data from cases were divided into two groups according to their HbA1c levels: group 1 (HbA1c<7, n=26) and group 2 (HbA1c>7, n=37). Data were analyzed statistically.ResultsMean ionic calcium levels in group 1 and group 2 were 1.1310.073 mmol/dL and 1.170 +/- 0.070 mmol/dL, respectively. In group 1, 11 out of 26 had EZ disruption (42.3%). Similarly, in group 2, 29 out of 37 had EZ disruption (78.4%). On logistic regression analysis, as compared to group 1, ellipsoid zone disruption was found to be positively associated with serum ionic calcium (p=0.01) in group 2 cases.Conclusionp id=ParIncreased levels of serum ionic calcium are associated with increased EZ disruption in patients with HbA1c>7 in DR. |