Publication details

Dlouhé nekódující RNA jako diagnostické biomarkery renálního karcinomu

Title in English Long non-coding RNAs as diagnostic biomarkers of renal cancer
Authors

FEDORKO Michal KUBÍČKOVÁ Adéla KOVÁČOVÁ Júlia PACÍK Dalibor SLABÝ Ondřej

Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Renal carcinoma (RCC) is most commonly diagnosed at random during an examination for other causes. At present, there is no sufficiently sensitive and reliable bio-marker capable of predicting the development of the disease and expecting a reasonable therapeutic response. Potential biomarkers are long non-coding RNAs (lncRNAs), molecules regulating gene expression at all levels, whose deregulation has been described in various cancers including RCC. The aim of this work was to analyze expression profiles of lncRNA, compare them with clinical pathological parameters and characterize their functionality in vitro.