Publication details

Stanovení vybraných žlučových kyselin ve slinách metodou HPLC-MS jako potenciální nová neinvazivní metoda diagnostiky Barrettova jícnu

Title in English Determination of selected bile acids in saliva by HPLC-MS as a potential new non-invasive method of diagnosis of Barrett's esophagus
Authors

KONEČNÝ Štefan DOLINA Jiří KUBÁŇ Petr ĎURČ Pavol DOSEDĚLOVÁ Věra HIMMELSBACH Markus BUCHBERGER Wolfgang

Year of publication 2019
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Barrett's esophagus is a term for a condition in which intestinal metaplasia occurs in the esophageal mucosa due to pathological reflux. This change is associated with an increased risk of developing oesophageal adenocarcinoma. The diagnosis of Barrett's esophagus is currently based on endoscopy with histological examination of the biopsied material. Experimental, clinical and immunohistochemical studies have shown that one of the factors in the pathogenesis of Barrett's esophagus is duodenal reflux and the related synergistic damage to the esophagus due to bile acids and gastric acid in the refluxate.
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