Publication details

Syndrom maligní hypertermie

Title in English Malignant hyperthermia syndrome
Authors

ŠTĚPÁNKOVÁ Dagmar KLINCOVÁ Martina

Type Chapter of a book
MU Faculty or unit

Faculty of Medicine

Citation
Attached files
Description Malignant hypertension can be defined as a rare but potentially life-threatening pharmacogenetic disease. After exposure to triggers, which are all volatile anesthetics and depolarizing relaxants, a genetically predisposed individual develops a pathological hypermetabolic response associated with a rapid and uncontrolled rise in myoplasmic Ca 2+, in the most severe cases ending in multiorgan failure and death.