Publication details

Anterior thalamic deep brain stimulation in epilepsy and persistent psychiatric side effects following discontinuation

Authors

DOLEŽALOVÁ Irena KUNST Jonáš KOJAN Martin CHRASTINA Jan BALÁŽ Marek BRÁZDIL Milan

Year of publication 2019
Type Article in Periodical
Magazine / Source Epilepsy and Behavior Reports
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.sciencedirect.com/science/article/pii/S2589986419301297?via%3Dihub
Doi http://dx.doi.org/10.1016/j.ebr.2019.100344
Keywords Case report; Deep brain stimulation of the anterior nucleus of the thalamus
Description We report a case of a patient with drug-resistant epilepsy treated with deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS). The patient developed psychiatric side effects (PSEs), namely irritability, hostility, aggressiveness, and paranoia, after implantation and stimulation initiation. The stimulation was discontinued and the PSEs were mitigated, but the patient did not return to her pre-implantation state, as documented by repeated psychiatric reports and hospitalizations. To our knowledge, this is the first report of a patient who developed long-term PSEs that did not disappear after stimulation discontinuation. We suppose that ANT-DBS caused a persistent perturbation of the thalamic neuronal networks that are responsible for long-term PSEs.
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