Publication details
Severe hyperuricemia in two children with acute gastroenteritis: answers
| Authors | |
|---|---|
| Year of publication | 2020 |
| Type | Article in Periodical |
| Magazine / Source | Pediatric Nephrology |
| MU Faculty or unit | |
| Citation | |
| Web | https://link.springer.com/article/10.1007/s00467-020-04493-8 |
| Doi | http://dx.doi.org/10.1007/s00467-020-04493-8 |
| Keywords | severe hyperuricemia; acute gastroenteritis; children |
| Description | Uric acid (UA) is the end product of purine catabolism in humanoids, since the hepatocyte enzyme uricase, which degrades UA to allantoin in other mammals, is completely inactive. Approximately 65–75% of the UA produced daily is excreted by the kidneys, while the remaining 25–35% exits in the stool. Homeostasis of UA is determined by the balance between production and excretion. Hyperuricemia is caused by all conditions associated with increased purine synthesis and degradation during excessive cell breakdown and follow-up catabolism of nucleic acids, or an inability of the kidneys and gastrointestinal tract relative to urate excretion and clearance. During childhood, it is important to evaluate age- and sex-related serum UA concentration with respect to reference values. |