Publication details

Direct fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids in polyacrylamide gels

Authors

PEKAŘÍK Vladimír KUDLIČKOVÁ PEŠKOVÁ Marie DUBEN Jakub REMES Marek HEGER Zbynek

Year of publication 2020
Type Article in Periodical
Magazine / Source Scientific reports
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.nature.com/articles/s41598-020-69336-w.pdf
Doi http://dx.doi.org/10.1038/s41598-020-69336-w
Keywords Direct fluorogenic detection; palladium and platinum organometallic complexes; polyacrylamide gels
Description Allyl- and propargyl ethers of umbelliferone are sensitive probes for palladium and platinum, including anticancer compounds cisplatin, carboplatin and oxaliplatin, and effective for direct visualization of protein and DNA complexes with organometallic compounds in polyacrylamide gels allowing easy detection of interactions with analyzed protein or nucleic acid. Both probes can be used for fast evaluation of Pd/Pt binding to nanocarriers relevant in drug targeted therapy or specific clinically relevant target macromolecules.
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