Publication details

Toward more accurate data in cardiac cellular electrophysiology



Year of publication 2020
Type Article in Periodical (without peer review)
MU Faculty or unit

Faculty of Medicine

Description The divergence of published data is a well-recognised problem of experimental sciences including cardiac cellular electrophysiology. Differences in experimental conditions as well as in experimental models are commonly known to be potential reasons for this. Properties of individual cardiac myocytes vary depending on their localisation in the heart muscle, but also differ among species and strains, age and gender groups, housing and health conditions, to name the most often discussed sources of variability. However, limits of accuracy of experimental data arising from sub-optimal measurement and evaluation methods represent another important and often neglected source of data inconsistency. The term accuracy stands often for both the closeness of measured values to the true value of a parameter and the closeness of individual measurements to each other (the latter is also called precision). Both these aspects of accuracy are indeed essential to obtain data as close to reality as possible. This Special Issue is therefore aimed to address methodological factors that should be considered to minimize variability and inconsistency, or in other words, to maximize reproducibility of electrophysiological studies.

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