Publication details

Obalené sférické matricové pelety určené k adjustaci do detekčních trubiček k detekci inhibitorů cholinesteráz

Title in English Coated spherical matrix pellets for adjustment into detection tubes to detect cholinesterase inhibitors


Year of publication 2020
Type Patent
MU Faculty or unit

Faculty of Pharmacy

State Czech Republic
Patent's number 308597
Description Coated spherical matrix pellets, consisting of a core and a coating, containing an immobilized enzyme based on cholinesterases such as acetylcholinesterase and/or butyrylcholinesterase, with an activity of 1 to 100 kat.g-1, wherein the enzyme is in the cores immobilized on a porous, water-insoluble anorganic material, preferably aluminium metasilicate, and these cores are coated with a semipermeable coating of a water-insoluble polymer, preferably based on acrylate derivatives, where the total concentration of the coating is 1 to 10 % weight of coated spherical matrix pellets and the average size of coated spherical matrix pellets being at least from 75 % in the range of 0.1 to 3.0 mm, preferably 0.8 to 1.25 mm, wherein the pellet cores are produced by extrusion-spheronization and the coating is applied by fluid bed spraying and the resulting coated spherical matrix pellets are used to detect cholinesterase inhibitors in the form of a detection tube containing such coated spherical matrix pellets.

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