Publication details
Obalené sférické matricové pelety určené k adjustaci do detekčních trubiček k detekci inhibitorů cholinesteráz
| Title in English | Coated spherical matrix pellets for adjustment into detection tubes to detect cholinesterase inhibitors |
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| Authors | |
| Year of publication | 2020 |
| Type | Patent |
| MU Faculty or unit | |
| Publisher | |
| State | Czech Republic |
| Patent's number | 308597 |
| Web | https://isdv.upv.cz/doc/FullFiles/Patents/FullDocuments/308/308597.pdf |
| Description | Coated spherical matrix pellets, consisting of a core and a coating, containing an immobilized enzyme based on cholinesterases such as acetylcholinesterase and/or butyrylcholinesterase, with an activity of 1 to 100 kat.g-1, wherein the enzyme is in the cores immobilized on a porous, water-insoluble anorganic material, preferably aluminium metasilicate, and these cores are coated with a semipermeable coating of a water-insoluble polymer, preferably based on acrylate derivatives, where the total concentration of the coating is 1 to 10 % weight of coated spherical matrix pellets and the average size of coated spherical matrix pellets being at least from 75 % in the range of 0.1 to 3.0 mm, preferably 0.8 to 1.25 mm, wherein the pellet cores are produced by extrusion-spheronization and the coating is applied by fluid bed spraying and the resulting coated spherical matrix pellets are used to detect cholinesterase inhibitors in the form of a detection tube containing such coated spherical matrix pellets. |