Publication details

Electrochemical reduction and oxidation of eight unnatural 2 '-deoxynucleosides at a pyrolytic graphite electrode



Year of publication 2020
Type Article in Periodical
Magazine / Source Electrochimica Acta
MU Faculty or unit

Central European Institute of Technology

Keywords Electrochemistry; Electrochemical oxidation; Electrochemical reduction; Pyrolytic graphite; Unnatural DNA
Description Recently we showed the reduction and oxidation of six natural 2'-deoxynucleosides in the presence of the ambient oxygen using the very broad potential window of a pyrolytic graphite electrode (PGE). Using the same procedure, 2'-deoxynucleoside analogs (dNs) that are parts of an artificially expanded genetic information system (AEGIS) were analyzed. Seven of the eight tested AEGIS dNs provided specific signals (voltammetric redox peaks). These signals, described here for the first time, will be used in future work to analyze DNA built from expanded genetic alphabets, helping to further develop AEGIS technology and its applications. Comparison of the electrochemical behavior of unnatural dNs with the previously documented behaviors of natural dNs also provides insights into the mechanisms of their respective redox processes. (C) 2020 Elsevier Ltd. All rights reserved.
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