Publication details
Laboratorní diagnostika imunitně podmíněných trombocytopenií
| Title in English | Laboratory testing of immune-mediated thrombocytopenias |
|---|---|
| Authors | |
| Year of publication | 2021 |
| Type | Article in Periodical |
| Magazine / Source | Transfuze a hematologie dnes |
| MU Faculty or unit | |
| Citation | |
| Web | https://www.prolekare.cz/en/journals/transfusion-and-haematology-today/2021-3-16/laboratorni-dia-gnostika-imunitne-podminenych-trombocytopenii-128147 |
| Doi | http://dx.doi.org/10.48095/cctahd2021232 |
| Keywords | HLA; HPA; Immune-mediated thrombocytopenia |
| Attached files | |
| Description | Immune-mediated thrombocytopenias are caused by alloantibodies or autoantibodies directed against platelet surface antigens. This group of immune disorders is divided into five types of thrombocytopenias in which platelet antibody testing is possible: immune thrombocytopenia, drug-induced immune thrombocytopenia, foetal and neonatal alloimmune thrombocytopenia, post-transfusion purpura, multi-platelet transfusion refractoriness. Laboratory testing involves detection and identification of patient serum antibodies using indirect tests or antibodies attached to patient platelets using direct tests. The analysis of blood samples for platelet antibody detection is complicated due to insufficient sensitivity of some laboratory tests. Identification of platelet-specific HPA antibodies provides important information, which facilitates the clinical diagnosis of immune-mediated disorder. |