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Je možné pozorovat etnickou diferenci v základních krevních testech? Údaje z programu onkologické prevence v komplexním onkologickém centru v České republice

Title in English Can we Observe Ethnic Difference in Basic Blood Tests? Single-institution Data from Cancer Prevention Programme in the Czech Republic


Year of publication 2017
Type Article in Periodical
Magazine / Source Klinická onkologie
Keywords lab tests - reference range - ethnic specificity
Description Background: Laboratory tests are standard part of a routine check-up of current medical status and an important tool in diagnostic workup, in planning or evaluation of treatment, and disease monitoring. To reduce misdiagnosis, accurate reference intervals reflecting age, sex, ethnicity and other relevant clinical parameters must be established. We aimed to explore ethnic difference in basic blood parameters relevant for the Czech Republic. Patients and methods: The study was performed analyzing blood tests from 13,126 individuals in cancer prevention program. Individuals were divided into two subgroups - 1. Czech, 2. Vietnamese, and laboratory parameters were compared. Results: Statistically significant differences were observed in majority of basic blood tests. These could be explained either by ethnical differences in basic biological parameters (weight, body mass) or dietary habits, such as in case of lower blood cholesterol levels and lower creatinine levels respectively in individuals of Vietnamese origin. Observed differences in erythrocyte-related parameters likely reflect higher incidence of haematogical disorders such as hemoglobinopathies. Conclusion: We observed statistically significant difference in basic blood tests between individuals of Czech and Vietnamese origin. Taking into consideration routinely used creatinine-based estimation of glomerular function, the most clinically relevant ethnic-based difference is substantially lower creatinine plasma level in individuals of Vietnamese origin.

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