Publication details

NAChRDB: Interactive annotations to untangle allostery of nicotinic acetylcholine receptor


CHARESHNEU Aliaksei PANT Purbaj TRISTAO RAMOS Ravi José SEHNAL David GÖKBEL Tugrul IONESCU Crina-Maria KOČA Jaroslav

Year of publication 2021
Type Conference abstract
MU Faculty or unit

Central European Institute of Technology

Description Nicotinic acetylcholine receptor (nAChR) is an ancient allosteric membrane protein mediating synaptic transmission. These prototypic pentameric ligand-gated ion channels are expressed in many tissues & species, being involved in cognition, metabolism, neuromuscular transmission, and many pathologies (myasthenia gravis, Parkinson & Alzheimer diseases, addictions). Since its isolation in 1970, studies produced >5000 publications with huge amounts of structural-functional data. However, cumulative residue-level knowledge on nAChRs is not systematically accessible. Scatteredness of literature data, aliases, various receptor types & residue numberings make it harder to summarize current knowledge and apply it efficiently to promote further discoveries. There is no single resource providing access to & visualization of such information. NACHRDB fills this gap, delivering relevant structural-functional data together with computational predictions of allosterically important residues, and facilitating its interpretation via interactive 3D visualization & sequence alignment. It can help to study allosteric regulation, reveal gaps in current knowledge, and guide further studies in the field.

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