Publication details

Web-based tools for computational enzyme design

Authors

MARQUES Sérgio Manuel PLANAS IGLESIAS Joan DAMBORSKÝ Jiří

Year of publication 2021
Type Article in Periodical
Magazine / Source Current Opinion in Structural Biology
MU Faculty or unit

Faculty of Science

Citation
Web https://www.sciencedirect.com/science/article/pii/S0959440X21000233?via%3Dihub
Doi http://dx.doi.org/10.1016/j.sbi.2021.01.010
Keywords PROTEIN; STABILITY; DYNAMICS; VIEW
Description Enzymes are in high demand for very diverse biotechnological applications. However, natural biocatalysts often need to be engineered for fine-tuning their properties towards the end applications, such as the activity, selectivity, stability to temperature or co-solvents, and solubility. Computational methods are increasingly used in this task, providing predictions that narrow down the space of possible mutations significantly and can enormously reduce the experimental burden. Many computational tools are available as web-based platforms, making them accessible to non-expert users. These platforms are typically user-friendly, contain walk-throughs, and do not require deep expertise and installations. Here we describe some of the most recent outstanding web-tools for enzyme engineering and formulate future perspectives in this field.
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